Only certain "nephritogenic" strains of β-hemolytic streptococci, localized to the pharynx or skin.
pneumococcal and staphylococcal infections as well as several common viral diseases such as mumps, measles, chickenpox, and hepatitis B and C. Endogenous antigens, as occur in SLE, can also cause similar diffuse proliferative GN
uniformly increased cellularity of the glomerular tufts that affects nearly all glomeruli, hence the term "diffuse” due to neutrophilic and monocytic infiltrate
Crescent formation if it progresses to RPGN( Rapidly progressive GN)
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