Hypertrophic Obstructive Cardiomyopathy( HOCM)idiopathic hypertrophic subaortic stenosis( IHSS)asymmetric septal hypertrophy
AD disease in 50% with defects in genes for troponin, tropomyosin and myosin
Hypertrophy of septum more than ventricular wall causing diastolic dysfunction and obstructionof outflow, with hyperkinetic contraction and LA dilation
Morphology:
M/E haphazard array of hypertrophied abnormally branching myocytes with connective tissue deposition
C/F
Exertional dyspnea, angina, CHF
Arythmia causing sudden cardiac death
ejection systolic murmur in aortic area radiating to carotids
Increased risk of infective endocarditis
0 comments:
Post a Comment