Myxedema

apathy and mental sluggishness that may mimic depression

cold intolerant, and often obese.

Mucopolysaccharide-rich edema accumulates in skin and tissues, causing broadening and coarsening of facial features, enlargement of the tongue, and deepening of the voice.

Bowel motility is decreased, resulting in constipation.

Pericardial effusions are common;

heart is enlarged, and heart failure may supervene.